O superastro do basquete LeBron James se junta à gangue Looney Tunes para derrotar o Goon Squad e salvar seu filho.
LeBron James
Al G. Rhythm
Dominic 'Dom' James
Bugs Bunny / Sylvester / Yosemite Sam / Fred Flintstone (voice)
Speedy Gonzales (voice)
Lola Bunny (voice)
Daffy Duck / Porky Pig / Foghorn Leghorn / Elmer Fudd (voice)
Granny (voice)
Tweety Bird (voice)
Taz (voice)
Diretor